EGFR and HER2neu Expression in Gall Bladder Carcinoma and Its Association with Clinicopathological Parameters - An Institutional Experience from North India

Objective: Gallbladder cancer (GBC) is the most common biliary tract malignancy found worldwide with very high incidence in North India especially Delhi region. It characterized by poor prognosis and ineffective treatment advanced stage. The aim of this study was to evaluate EGFR HER2/neu immunoexpression patients correlate it clinicopathological parameters so as identify GBC who can benefit from targeted therapy.Methods: Present conducted Department Pathology, Hamdard Institute Medical Sciences & Research, New Delhi. A total 40 cases carcinoma were evaluated for Immunohistochemical expression HER2/neu. Clinicopathological studied correlated HER2 /neu. Result: mean age 55.9 years 90% being females. On histopathology, 34(85%) conventional adenocarcinoma. positive 29/40 (72.5%). significantly more poorly differentiated grade stages gall bladder (P<0.05). 13/40 (32.5%). well Immunoexpression inversely related association statistically significant.Conclusion: Among patients, 72.5% 32.5%, respectively. Significant seen stage cancers while significant carcinomas. To conclude, these two markers be used predictive prognostic respectively, rationale further explore use anti-HER2 anti- therapy cancer.